Gastrointestinal Cancer (Esophagus, Gastric, Pancreatic, Hepatic, Colorectal and Anal), Lung Cancer
Conditions
Keywords
Gastrointestinal cancer, Lung cancer, Bioelectrical Impedance analysis, Body composition, Perioperative
Brief summary
Denutrition and Obesity are risk factors for perioperative surgical complications. In patient with cancer, incidence of denutrition is markedly increased. Surgical resection of cancer induces a high intensity cellular stress response and catabolism reinforcing the risk for perioperative denutrition. In this study, we thought to investigate the change in body composition during the perioperative period using anthropometric measurements and Bioelectrical Impedance Analysis (BIA).
Detailed description
Body composition measurements will be performed before surgical procedure (7 days) and at day 1, day 5, 1 month, 3 months and 6 months after surgery. Others data will be recorded including anthropometric measurements, nutritional intake, occurence of surgical complication, type of surgical procedure, type and stage of cancer, and CT-scan measurements of subcutaneous abdominal fat, visceral fat and peri-renal fat before surgery and at 6 months.
Interventions
Measurements of body composition including fat mass, lean body mass, muscular mass, mineral mass, total body water, intra and extracellular water.
Sponsors
Hôpital Européen Marseille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Gastrointestinal cancer (esophagus, gastric, pancreatic, hepatic, colorectal and anal) * Or Lung cancer * And planned surgical resection * Age \> 18 years
Exclusion criteria
* Surgical procedure planned \< 48 h * Pregnancy * Presence of a cardiac stimulator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| body composition | 1 month | The primary objective is to study the change in body composition (fat mass, lean body mass, muscular mass, mineral mass, total body water, intra and extracellular water) during the perioperative period with respect to short, mid and long term outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| perioperative complications | 6 months | One of the secondary objective is to investigate the relationship between baseline body composition and the occurrence of surgical complications. |
Other
| Measure | Time frame | Description |
|---|---|---|
| nutritional intake during perioperative period | 1 month | One of the secondary objective is to investigate the relationship between change in body composition and perioperative nutritional intake. |
| cancer type and stage | 6 months | One of the secondary objective is to investigate the relationship between baseline body composition and the type and stage of cancer. |
| comparison of the body composition obtained by BIA and anthropometric measurements. | 6 months | One of the secondary objective is to compare the body composition obtained by Bioelectrical Impedance Analysis (BIA) and by anthropometric measurements. |
Countries
France
Outcome results
None listed