Healthy
Conditions
Keywords
volunteers, young (18-30 y), older (65-75 y), age groups
Brief summary
The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.
Interventions
BEHAVIORALConcentric Exercise Training
8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
BEHAVIORALEccentric Exercise Training
8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
Sponsors
Biotechnology and Biological Sciences Research Council
University of Nottingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male volunteers * Body mass index 18-30 kg/m2 * Aged 18-35 and 65-75 years
Exclusion criteria
* Participation in a formal exercise regime, * A BMI \< 18 or \> 30 kg/m2, * Active cardiovascular disease, * Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs, * Cerebrovascular disease, * Respiratory disease, * Metabolic disease, * Active inflammatory bowel or renal disease, * Malignancy, * Recent steroid treatment (within 6 months) or hormone replacement therapy, * Clotting dysfunction, * Musculoskeletal or neurological disorders, * Family history of early (\<55y) death from cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein synthesis | 0 - 8 weeks | Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tendon protein synthesis | 0 - 8 weeks | Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training |
Other
| Measure | Time frame | Description |
|---|---|---|
| Muscle function | 0 - 8 weeks | Muscle strength, force and power in young and older individuals and in response to 8 weeks concentric or eccentric exercise training |
Countries
United Kingdom
Outcome results
None listed