Chronic Kidney Disease
Conditions
Brief summary
Chronic kidney disease is associated with the accumulation of various metabolites, i.e., uremic retention solutes. Evidence is mounting that the colonic microbiota contributes substantially to these uremic retention solutes. Indoxyl sulfate and p-cresyl sulfate are among the most extensively studied gut microbial metabolites, and are associated with cardiovascular disease, overall mortality and chronic kidney disease progression. The most important regulator of colonic bacterial metabolism is nutrient availability and especially the ratio of available fermentable carbohydrate to nitrogen, which can be modified by intake of so-called prebiotics (non-digestible food ingredients). Arabinoxylan oligosaccharides (AXOS) are a recently developed group of prebiotics, and already demonstrated a decreasing effect on intestinal generation of p-cresol in healthy individuals. Whether prebiotics in general, and AXOS more specifically, can influence intestinal generation of microbial metabolites in predialysis patients has not been studied to date. An interventional study with AXOS will therefore be initiated to test the hypothesis that AXOS can decrease intestinal generation and serum concentrations of microbial metabolites in patients with CKD not yet on dialysis.
Interventions
DIETARY_SUPPLEMENTArabinoxylan-oligosaccharides
DIETARY_SUPPLEMENTMaltodextrine
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 and ≤ 85 years * Chronic kidney disease stage 3b-4, i.e., with estimated glomerular filtration rate (CKD-epi) between 45 - 15 ml/min/m² 29 * Written informed consent
Exclusion criteria
* History of organic gastro-intestinal disease (e.g., inflammatory bowel disease, malignancy) * History of colonic surgery * Recipient of a renal or other solid organ transplant * Use of pre-/pro-/syn- or antibiotics in preceding 4 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of p-cresol and indole derivatives | After 4 weeks of intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Urinary excretion rates of p-cresol and indole derivatives | After 4 weeks of intervention | — |
| Insuline resistance | After 4 weeks of intervention | Insuline resistance, measured by HOMA index |
Countries
Belgium
Outcome results
None listed