Skip to content

Comparison of Bupivacaine and Exparel for Carpal Tunnel Release

Does Long-Acting Liposomal Bupivacaine Provide Improved Pain Relief Over Bupivicaine Alone in Carpal Tunnel Release?

Status
Withdrawn
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02141178
Enrollment
0
Registered
2014-05-19
Start date
2015-05-31
Completion date
2015-12-31
Last updated
2016-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain After Carpal Tunnel Release

Brief summary

Carpal tunnel syndrome is one of the most common surgeries performed per year in the United States, accounting for over 600,000 surgeries. The procedure is commonly performed under light sedation and local anesthesia. Bupivicaine, a long acting local anesthetic, has been used to allow extended pain relief for 8-10 hours after carpal tunnel release. Exparel, a liposomal bupivicaine formulation, has been documented to provide pain relief for up to 72 hours post-operatively. By decreasing post-operative pain through the use of a long-acting local anesthetic, the use of narcotic pain medications may be decreased and patient satisfaction scores may increase. The purpose of this study is to prospectively compare bupivicaine and liposomal bupivicaine with respect to post-operative pain control, narcotic usage, and patient satisfaction after carpal tunnel release.

Interventions

DRUGBupivacaine
DRUGExparel

Sponsors

University of Pittsburgh
Lead SponsorOTHER

Study design

Primary purpose
TREATMENT

Eligibility

Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
No

Inclusion criteria

* Patients with carpal tunnel syndrome undergoing surgery

Exclusion criteria

* Non english speaking * Allergy to bupivacaine or exparel

Design outcomes

Primary

MeasureTime frameDescription
PainStarting immediately after surgery and then every 8 hours for 10 daysPain will be evaluated using an 11-point ordinal scale (0-10)

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026