Perioperative Inflammation and Breast Cancer Outcome

Suppression of Inflammation by Using NSAIDs During Peri-operative Period Can Affect the Prognosis of Breast Cancer.

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02141139

Enrollment

1568

Registered

2014-05-19

Start date

2014-09-30

Completion date

Unknown

Last updated

2014-05-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Neoplasms

Keywords

Anti-Inflammatory Agents, Non-Steroidal, Inflammation, Perioperative Period

Brief summary

It is increasingly recognized the NSAIDS (nonsteroidal antiinflammatory drug) might prevent the several cancers. In breast cancer, the role of NSAIDS (nonsteroidal antiinflammatory drug) has been suggested.However, there was no consistent results. surgery is main cause of inflammation for cancer patients. Therefore, we want to know the association between prevention of perioperative inflammation with NSAIDS and breast cancer outcomes.

Interventions

DRUGNSAIDS (ketorolac and ibuprofen)

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Breast cancer patients who took the surgery

Exclusion criteria

* underlying medical disease (major heart disease, lung disease, coagulopathy) * major psychologic disease (major depression, schizophrenia, manic disorder) * pregnancy * rheumatic disease patients

Design outcomes

Primary

Measure	Time frame
disease free survival	5 years

Secondary

Measure	Time frame
overall survival	5years

Other

Measure	Time frame
neutrophil-lymphocyte ratio (NLR), albumin, inflammatory blood lab (CRP)	POD 1-2 weeks (immediate postoperative period)

Countries

South Korea

Contacts

Primary ContactSe Kyung Lee, M.D.

sekyung.lee@samsung.com82-10-3014-0110

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026