Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women

Endometrial Scratching at Time of Laproscopic Ovarian Drilling in Women With Anovulatory Infertility Due to Polycystic Ovarian Syndrome (PCOS): Randomized Controlled Trial.

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02140398

Acronym

ESLOD

Enrollment

500

Registered

2014-05-16

Start date

2014-04-30

Completion date

2015-10-31

Last updated

2014-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility, Polycystic Ovarian Syndrome

Keywords

infertility, PCOS, scratching, endometrial receptivity

Brief summary

Laparoscopic Ovarian Drilling is a valid procedure for infertile anovulatory women with polycystic ovarian syndrome who failed to get pregnant or to ovulate with ovulation induction medications as clomiphene citrate or exogenous gonadotropins. The reasearchers supposed that endometrial curettage at time of laparoscopic ovarian drilling may boost fertility in these women.

Detailed description

Current literature suggests that endometrial biopsy may improve pregnancy rates in infertile women hence the investigators will examine whether this hypothesis will apply to infertile PCOS women undergoing laparoscopic ovarian drilling to overcome ovulatory disfunction or not.

Interventions

PROCEDUREEndometrial Currettage

Only Laparoscopic ovarian drilling without endometrial currettage will be performed

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 39 Years

Healthy volunteers

Inclusion criteria

1. subfertile women with anovulatory infertility due to polycystic ovarian syndrome (PCOS). 2. Women who failed to get pregnant after at least 6 months of ovulation induction cycles with clomiphene citrate or exogenous gonadotropins 3. Patent Fallopian tubes as confirmed by hysterosalpingography 4. Fertile semen parameters of the partneraccording to criteria of World Health Organization (WHO 2010).

Exclusion criteria

1. women with BMI \>30, 2. age \< 18 years or \> 39 years, 3. women with ovarian cysts identified by transvaginal ultrasound 4. male factor infertility 5. Tubal factor infertility as suggested by hystrosalpingogram (HSG) 6. Women with congenital malformations in the uterus as bicornuate or septate uterus as suggested by HSG.

Design outcomes

Primary

Measure	Time frame
live birth rate per woman randomized	15 months

Secondary

Measure	Time frame
pregnancy rate per woman randomised	6 months

Other

Measure	Time frame
miscarriage rate time to pregnancy interval	6 months

Countries

Egypt

Contacts

Primary ContactAhmed Gibreel, MD

ahmedfathgi@yahoo.com00201004045733

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026