Metabolism
Conditions
Brief summary
Capsaicinoids (the active ingredient in hot peppers) have been shown to cause a moderate increase in energy expenditure (50 kcal/day) as well as reductions in appetite, energy intake, and (visceral) adiposity. As such, there is considerable interest in capsaicinoid for weight loss supplements. Of particular interest are the recent findings that free-fatty acids in the blood are elevated 2-2.5hrs post ingestion, yet changes in typical cardiovascular or sympathetic nervous tone indicators (heart rate, blood pressure) were unaffected, suggesting some of the negative consequences of other stimulants may be avoided. At present, however, more in depth investigations of the effects on endothelial function, vascular autonomic tone and inflammation are lacking. The investigators seek to understand the effect of 3 months capsaicinoid ingestion on alterations in body composition, traditional cardiovascular risk factors and cardiovascular function Hypotheses: 1\) Continued use of capsaicinoids will alter resting metabolism substrate use, which will result in moderate (but clinically meaningful) alterations in body composition manifested as a decrease in adiposity. 2) Blood lipids will be unaffected by capsaicinoid use, as will brachial blood pressure. 3) Levels of systemic inflammation may increase slightly, and this could have an effect on vascular reactivity to hyperemic flow or baseline vascular tone. However, previous research suggests that these alterations will not be manifested in autonomic nervous tone assessed by changes in heart rate variability.
Detailed description
Project abandoned
Interventions
DIETARY_SUPPLEMENTCapsaicin
Sponsors
OmniActive Health Technologies
University of Prince Edward Island
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects will be male or female * 18 yr -45yr and free from any known or suspected chronic conditions. * General health and suitability to participate in an exercise/health research study will be confirmed through use of the PAR-Q+ screening questionnaire
Exclusion criteria
* Any participant who has a positive answer to a screening question will be required to seek physician approval prior to any physical exercise. * Baseline arrhythmia (tachycardia (\>100pbm) and systolic or diastolic hypertension (\>140/90 mmHg) will also be reason for exclusion. * During baseline anthropometric assessment we will confirm that participants all fall within a typical BMI range (20-30 kg/m2) of either normal weight or overweight, but not underweight or obese. * Persons who take cardiovascular medications, metabolic medications, smoke cigarettes, excessively consume alcohol, are prone to heartburn, or have a previous diagnosis of hyperlipidemia or hyperinsulemia will also be excluded
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy substrate use (Fat vs Carbohydrate contributions to metabolism) | 10 weeks | Expired gas analysis using a metabolic computer to calculate respiratory exchange rates. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular risk factors | 10 weeks | Vascular reactivity- endothelial function (Endopat), vascular stiffness (Pulse wave velocity), HRV (heart rate variability), Blood lipid/Glucose panel, blood pressure |
Countries
Canada
Outcome results
None listed