Hemodynamic Repercussions of Noninvasive Ventilation

Evaluation of the Hemodynamic Repercussions of Non Invasive Ventilation in Healthy Individuals by Doppler Echocardiography

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02139631

Enrollment

Registered

2014-05-15

Start date

2014-05-31

Completion date

2014-11-30

Last updated

2015-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Haemodynamic Rebound

Keywords

hemodynamic, mechanical ventilation, respiration with positive pressure

Brief summary

The noninvasive ventilation (NIV) is a method of ventilatory support that does not require artificial airway. Its application is associated with complex hemodynamic repercussions, therefore is important to identify them for safety and effectiveness of the technique application. The main objective of this research is to evaluate the hemodynamic repercussions using doppler echocardiography in healthy volunteers submitted a different values of positive end expiratory pressure (PEEP) by the following ventilatory modes: Continuous positive airway pressure (CPAP) and Bilevel. The study hypothesis is that the positive end expiratory pressure (PEEP) may cause hemodynamic repercussions as: reduction of the ventricles pre-load, left ventricle after load, cardiac output and reduction in the diameter of the superior vena cava, due to the increase in the intrathoracic pressure and pulmonary volumes.

Interventions

OTHERNoninvasive ventilation

Assess the hemodynamic repercussions of the positive end expiratory pressure applied noninvasively

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy individuals * Age between 18 and 40 years old * Non smoker

Exclusion criteria

* Clinical signs or symptoms of any disease decompensation * History of blood pressure variations by autonomic dysfunction * Sense of claustrophobia * Smoker

Design outcomes

Primary

Measure	Time frame	Description
Hemodynamic repercussions of different levels of positive end expiratory pressure applied noninvasively, measured by echocardiography	5 minutes	The hemodynamic variables evaluated are: ventricular preload, left ventricle afterload, cardiac output, blood pressure and the vena cava's diameter. All variables will be assessed by echocardiography

Secondary

Measure	Time frame
Measurement of cardiac output as a predictor of cardiopulmonary adaptation to different pressures.	5 minutes

Other

Measure	Time frame
Difference between the hemodynamic effects generated by ventilation modes CPAP and Bilevel	3 hours

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026