Coronary Artery Bypass Graft Triple Vessel, Hypotension
Conditions
Brief summary
The purpose of this study is to assess the effects of ramosetron on corrected QT interval in patients undergoing off pump coronary artery bypass surgery.
Interventions
DRUGRamosetron
0.3 mg IV as bolus before induction of general anesthesia
DRUGNormal saline
2 ml normal saline as bolus before induction of general anesthesia
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Elective off-pump coronary artery bypass graft surgery
Exclusion criteria
* Emergency operation * preoperative use of any inotropics or mechanical assist device * severe liver disease (\>Child class II) * dialysis dependent renal failure * Left ventricular ejection fraction \<30 % * Combined major surgery like carotid endarterectomy * Previous allergy history to any 5-hydroxytryptamine type 3 (5-HT3) antagonist * Preoperative QT prolongation ( 500 \>msec) or arrhythmia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| corrected QT interval (QTc interval) | up to 240 minutes after induction of general anesthesia | at 1,2,3,5,10,15,30,45,60,90,120,240 minutes after ramosetron injection, at the time of operation end, ICU 12hour |
Secondary
| Measure | Time frame |
|---|---|
| hypotension or bradycardia during the peri-induction period and the coronary anastomosis period | up to 240 minutes after induction of general anesthesia |
| incidence of postoperative atrial fibrillation | during the hospital stay (from ICU admission to hospital discharge, average of 1 week) |
Countries
South Korea
Outcome results
None listed