Acute Renal Failure, Anuria, Obstructive Uropathy, Ureteric Stones
Conditions
Keywords
anuria, children, ureteroscopy, initial urinary drainage, ureteric stones
Brief summary
To compare staged ureteroscopy following initial urinary drainage versus direct ureteroscopy without initial urinary drainage in the treatment of obstructive calcular anuria with acute renal failure in children.
Detailed description
To compare staged ureteroscopy following initial urinary drainage and stabilization of renal functions using percutaneous nephrostomy or double J stent versus direct ureteroscopy without initial urinary drainage in the treatment of obstructive calcular anuria with acute renal failure due to ureteric calculi in children.
Interventions
PROCEDUREinitial urinary drainage
initial urinary drainage is done using nephrostomy or double J stent to stabilize renal functions. this is followed several days later by definitive ureteroscopy.
PROCEDUREdirect ureteroscopy
direct ureteroscopy is done without initial urinary drainage and before return to normal chemistry. this is followed follow-up of renal functions for several days before treatment of the contralateral side.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 12 Years
Healthy volunteers
No
Inclusion criteria
* children ≤12 years old presenting with Obstructive Anuria and Acute Renal Failure due to bilateral ureteric stones suitable for ureteroscopy.
Exclusion criteria
* Fever, pyonephrosis or sepsis. * unstable patients are stabilized first by dialysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Return to normal creatinine | 1 week | period for return to normal creatinine in both groups |
| stone free status | 1 week | success in removal of ureteric stones using ureteroscopy |
| operative and early post operative complications | 1 week | Hematuria, Extravasation (perforation), mucosal complications, stone migration, failure of ureteric access, fever |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ureteric stricture | 6 months | occurrence of ureteric stricture as a delayed complication |
| period to reach stone free status bilaterally | 6 months | period to reach stone free status bilaterally after the treatment of the contralateral side |
| number of times of exposure to general anesthesia | 6 months | number of times of exposure to general anesthesia during successive interventions to clear stones bilaterally |
Countries
Egypt
Contacts
Primary ContactMohammed S ElSheemy, A Professor
Outcome results
None listed