Effect of Bariatric Surgery on Kidney Function

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02138565

Acronym

GAS

Enrollment

Registered

2014-05-14

Start date

2014-03-31

Completion date

2017-09-30

Last updated

2018-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obese Subjects Who Will Undergo Gastric By-pass Surgery

Brief summary

Primary hypothesis: A large reduction in weight is not associated with a change in accurately measured glomerular filtration rate (GFR) (51Chromium ethylenediaminetetraacetic acid plasma clearance (51Cr-EDTA)). Secondary hypothesis: A large reduction in weight is associated with a greater change in estimated GFR (The Modification of Diet in Renal Disease (MDRD-formula)) than in accurately measured GFR. Other formulas for estimated GFR (Cockcroft Gault, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI with cystatin C) are better correlated with accurately measured GFR.

Interventions

PROCEDUREGastric by-pass surgery

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Male or female, older than 18 years of age * Appointed to gastric by-pass surgery on Hvidovre Hospital, Denmark

Exclusion criteria

* Withdrawal of surgical indication * Severe oedema or ascites

Design outcomes

Primary

Measure	Time frame
Change in accurately measured GFR	Up to 6 months and 18 months after surgery

Secondary

Measure	Time frame
Change in estimated GFR (as measured by the MDRD formula, the Cockcroft Gault formula, CKD-EPI formula and CKD-EPI with cystatin C formula).	Up to 6 months and 18 months after surgery
Change in 24hour blood pressure	Up to 6 months and 18 months after surgery
Change in arterial stiffness (as measured by sphygmocor)	Up to 6 months and 18 months after surgery
Change in body composition, as measured by Dual-energy X-ray absorptiometry scan (DXA-scan)	Up to 6 months and 18 months after surgery
Change in accurately measured GFR compared with change in estimated GFR	Up to 6 months and 18 months after surgery

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 11, 2026