Assessment of Neuropathic Pain

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02138344

Enrollment

600

Registered

2014-05-14

Start date

2006-04-01

Completion date

2024-09-27

Last updated

2025-01-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Injury + Peripheral Nerve Diseases

Brief summary

Development of neuropathic pain is one of the most disabling sequels after spinal cord injury (SCI) and in peripheral nerve diseases. The functionality of the pain pathway in humans as well as its plastic changes following SCI can be assessed in vivo by surface electrophysiological recordings and functional magnetic resonance imaging after noxious heat stimulation of the skin. Aims: a) establishing a clinically applicable assessment of the pain pathway and characterizing its changes as a consequence of SCI and in peripheral nerve diseases in an objective manner, b) characterizing plastic changes in the pain pathway in SCI patients with neuropathic pain and in patients with peripheral nerve diseases and relating them to the development of neuropathic pain syndromes.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Uninjured * Scord injured subjects * Subjects with peripheral nerve diseases * Patients resident in Switzerland

Exclusion criteria

* Presence of any central psychiatric disorder (that precludes subject from giving informed and voluntary consent) * For fMRI measurements: yes for any item in the MR-risk questionnaire * Patients resident outside from Switzerland

Design outcomes

Primary

Measure	Time frame
Pain, sensory and autonomic assessments	2 - 4 weeks

Countries

Switzerland

Outcome results