Neuromuscular Disease
Conditions
Keywords
cough help, in-exsufflation, neuromuscular disease, cough assistance optimization, efficient cough flow
Brief summary
The investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
Detailed description
he investigators want to demonstrate that there is an optimal expiratory pressure when using mecanical in-exsufflation for each patient in neuromuscular disease. This compromise is between the need to generate a high pressure difference between alveoli and the mouth and the need to avoide and superior airways collapsus.
Interventions
DEVICECough Assist® (JH Emerson Compagny, Cambridge, MA, USA)
Cough Assist® (JH Emerson Compagny, Cambridge, MA, USA) mechanical insufflation to increase peak cough flow
Sponsors
Centre d'Investigation Clinique et Technologique 805
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* man or female age18 years * neuromuscular disease * coughassist adaptation treatment * peak cough flow\<270liter/minute
Exclusion criteria
* acute organ failure * insufflation contrindication * pregnant women/no affiliation to a social security scheme * plan of legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| optimal negative pressure treshold value | 20 minutes | Optimal negative pressure treshold value measured for a flow superior or equal to 160 liter/minute and 270 liter/minute |
Secondary
| Measure | Time frame |
|---|---|
| optimal pressure treshold based on the best peak flow. | 10 minutes |
| volume-flow curve aspect | 5 minutes |
Countries
France
Outcome results
None listed