Analgesic Response
Conditions
Keywords
pain, cold presser test, buprenorphine, opioids
Brief summary
The aim of this study is to examine the effects of opioid analgesics on acute pain in participants maintained on buprenorphine+naloxone (Suboxone) for opioid use disorders. Seven medication conditions will be tested in a cold pressor test (CPT) paradigm.
Detailed description
Study design is a single-blind examination of the analgesic effects of a single dose of seven test medications provided in an experimental pain paradigm using a cold pressor test (CPT). Test medication conditions include buprenorphine, morphine, hydromorphone, hydrocodone, oxycodone, and two placebo conditions to match test medication formulations (oral tablet, sublingual tablet). Each medication condition will be tested on separate days (seven total days, completing within 12 weeks), with random assignment to order of study medications. After screening, eligible participants will be scheduled for 7 days of testing with test days at least 3 days apart to provide a sufficient medication wash-out period. Pain testing will utilize cold pressor tests (CPT), in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance. Participants will be given a practice trial to provide familiarity with the test and reduce test anxiety. Two CPTs will occur on each test day, and pre- and post-CPT assessments will be administered. Blood samples will be taken on each test day to measure blood levels of buprenorphine. Daily procedures include: (1) A baseline CPT (BL-CPT), (2) Administration of the test medication (active drug or placebo), (3) CPT administered at the time of maximum drug effect (Tmax-CPT) specific to medication (range 30-120 minutes), (4) Pupillometry conducted at baseline (before BL-CPT), and at time of maximum drug effect (before Tmax-CPT). Each participant will be discharged after clinical determination of the participant's safety and well-being. Testing will continue until twelve trials of each medication condition are completed.
Interventions
DRUGmorphine sulfate
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGhydrocodone
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGhydromorphone HCI
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGoxycodone
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGbuprenorphine
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGoral tablet placebo
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
DRUGsublingual tablet placebo
Participants will receive randomly assigned order of study drug (opioid) and then have 7 days of testing with test days at least 3 days apart. Pain testing will utilize cold pressor test, in which the participant submerges his arm and hand in a bath of ice cold water to determine pain threshold and tolerance.
Sponsors
Indivior Inc.
University of California, Los Angeles
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
1. Male, in good general health 2. 20-50 years old 3. Fluent in English 4. Maintained on buprenorphine for at least 3 months 5. Able to complete testing/assessments for 7 test days within 12 weeks 6. Approved for participation by buprenorphine-prescribing physician
Exclusion criteria
1. Known hypersensitivity to any of the test opioids 2. Urine test positive for opioids (other than buprenorphine) or other illicit substances 3. Current use of any additional opioid or analgesic medication (other than buprenorphine), medical marijuana, MAOI, tricyclic antidepressant, duloxetine, gabapentin, pregabalin, or other medication considered unsafe or having potential to influence pain perception as determined by study physician. 4. Presence of acute pain condition or planned surgery during the study period 5. Unstable vital signs as determined by the study physician. 6. Current pattern of alcohol, benzodiazepine, or other sedative hypnotic use, as determined by the study medical clinician, which would preclude safe participation in the study; 7. Pending legal action or other situation that might prevent remaining in the area for the duration of the study 8. Current medical or psychiatric condition that could detract from study objectives, place the participant at risk, or interfere with treatment goals
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain detection | 7 testing sessions over 12 weeks | Pain detection is defined as the number of seconds it takes for the participant to feel pain. |
| Pain tolerance | 7 testing sessions over 12 weeks | Pain tolerance is defined as the number of seconds it takes before the participant removes his hand from the ice water. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pupillometry results | 7 testing sessions over 12 weeks | Examine pupillometry results in the context of administered opioid medications and associated cold pressor tests. |
Countries
United States
Contacts
Primary ContactJessica Jenkins, MA
Backup ContactMaureen Hillhouse, PhD
Outcome results
None listed