Theraphy of Chinese Traditional Medicine
Conditions
Keywords
Traditional Chinese Medicine
Brief summary
This study aims to discuss whether the combined treatment of traditional Chinese medicine (TCM) and western medicine for Mental Stress Induced Myocardial Ischemia (MSIMI) does effect, namely the conventional therapy for Coronary Heart Disease( CHD) combining with TCM - Xinkeshu tablets.
Detailed description
A large number of evidence-based medical researches have proven that bad mood and mental stress are related to poor prognosis. Having recognized that acute emotional stress can induce cardiovascular events, many clinical tests of mental stress have been carried out to observe the correlation between emotional stress and cardiac damage, which ultimately lead to the formalization of the concept of Mental Stress Induced Myocardial Ischemia(MSIMI). In the past 3 decades, it has been evidenced that mental stress is internally related to myocardial ischemia. According to current studies, over 70% patients with stable coronary heart disease have MSIMI and are exposed to three or four times higher risk of cardiovascular events. However, few articles are about the therapeutic effect of MSIMI treatment. This study aims to discuss whether the combined treatment of traditional Chinese medicine (TCM) and western medicine for MSIMI does effect, namely the conventional therapy for CHD combining with TCM - Xinkeshu tablets.
Interventions
DRUGXinkeshu tablets
4 Xinkeshu tablets are given three times per day
OTHERplacebo
the placebo is not drug.
Sponsors
Meiyan Liu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. above 18 years old, 2. having coronary stenosis (\> 70%) measured by coronary arteriography, 3. with medical history of myocardial infarction or revascularization procedures, 4. or with sufficient proof for having CHD.
Exclusion criteria
1. patient age younger than 18, 2. clearly impaired cognitive function, 3. damage of functions of vital organs, 4. suicidal ideation, 5. mental diseases treated with selective serotonin reuptake inhibitor (SSRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular ejection fraction | up to 8 weeks | reduction of LVEF by 5% or more |
| ventricular wall motion | up to 8 weeks | Echocardiography to assess the ventricular wall motion in one cardiac cycle starting from the systole |
Countries
China
Contacts
Primary ContactLiu Meiyan
Outcome results
None listed