Impaired Glucose Tolerance
Conditions
Brief summary
The number of people diagnosed with Type 2 diabetes (T2DM) is increasing rapidly and about 2.9 million people in the UK currently have diabetes. There is increasing evidence suggesting that prolonged sedentary time may actually increase the risk of diabetes and other chronic diseases. Importantly, adults can meet public health guidelines on physical activity (150 minutes of moderate activity per week), but if they still sit for prolonged periods, their metabolic health is compromised. Going from sitting to standing and carrying out light-intensity activities (such as casual walking) may reduce diabetes risk. However, no one has investigated the effect of standing and walking on markers of cardio-metabolic markers in individuals with a high risk of T2DM. Therefore, the aim is to find out whether reducing the amount of time people spend sitting and replacing it with standing and light intensity activity (walking) reduces glucose, insulin and triglyceride levels, therefore reducing the risk of diabetes.
Sponsors
National Institute for Health Research, United Kingdom
National Health Service, United Kingdom
University of Leicester
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* Sedentary * Overweight or obese (BMI\>25kg/m2) * Post menopausal * Previous diagnosis of impaired glucose tolerance
Exclusion criteria
* Regular purposeful exercise (≥150 minutes of MVPA per week) * Physical condition which limits full participation in the study * Active psychotic illness or other significant illness which, in the view of the investigators, would prevent full participation * Inability to communicate in spoken English * Steroid use * Known Type 2 Diabetes * Pregnancy * Male * Currently taking hormone replacement medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose area under the curve | 0 weeks and 2 weeks | Glucose area under the curve (AUC); Plasma glucose will be measured using a glucose oxidase method on the Beckman Auto Analyzer (Beckman, High Wycombe, UK). Glucose profile measurements will be undertaken in the same laboratory located within the Leicester Royal Infirmary. |
Secondary
| Measure | Time frame |
|---|---|
| Insulin area under the curve | 0 weeks and 2 weeks |
| Triacylglycerol area under the curve | 0 weeks and 2 weeks |
| Lipoprotein lipase activity | 0 weeks and 2 weeks |
Countries
United Kingdom
Outcome results
None listed