MRI Outcomes of Mindfulness Meditation for Migraine

Conditions

Migraine

Keywords

migraine, headache, meditation, mindfulness based stress reduction, MBSR

Brief summary

112 migraine subjects will be initially randomly assigned to Mindfulness-Based Stress Reduction (MBSR) or a Stress Management for Headache group (SMH). Outcomes, including headache frequency and impact and brain activity, will be assessed at baseline, prior to intervention, and at 3-, 6-, and 12-months.

Detailed description

Subjects in the MBSR group undergo a standardized 8-week MBSR course plus an additional 4 sessions over another 8 weeks that further emphasize and train subjects on MBSR concepts and skills. The SMH group will have 12 sessions spread out in a similar fashion to MBSR. Clinical outcomes are compared between groups at 3, 6, and 12 months to assess efficacy of MBSR. MRI scans are performed at baseline, 3 months, and 6 months changes in MRI metrics after MBSR and changes in MRI metrics associated with long-term MBSR practice. 30 healthy controls will also undergo MRI scanning to determine abnormal brain activity and structure in migraineurs compared to healthy controls across the 6 month period of observation.

Burrowes SAB, Goloubeva O, Keaser ML, Haythornthwaite JA, Seminowicz DA.

2021-10-232 citations

10.1186/s10194-021-01340-5

Enhanced mindfulness-based stress reduction in episodic migraine—effects on sleep quality, anxiety, stress, and depression: a secondary analysis of a randomized clinical trial

Shana Burrowes, Olga Goloubeva, Kristen A. Stafford, Patrick F. McArdle, Madhav Goyal et al. (8 authors)

Pain2021-06-1453 citations

10.1097/j.pain.0000000000002372

Conducting a pilot randomized controlled trial of community-based mindfulness-based stress reduction versus usual care for moderate-to-severe migraine: protocol for the Mindfulness and Migraine Study (M&M).

Pressman A, Law H, Stahl R, Scott A, Jacobson A, Dean L, Sudat S, Obillo A, Avins A.

2019-05-0611 citations

10.1186/s13063-019-3355-y

Interventions

BEHAVIORALMindfulness Based Stress Reduction

Mindfulness Based Stress Reduction (MBSR) involves focused attention while practicing moment-to-moment nonjudgmental awareness of the self with the goal of achieving emotional balance and clarity of thought. There will be 8 weekly sessions and a half day retreat followed by 4 bi-weekly sessions over a period of 4 months.

BEHAVIORALStress Management for Headaches

Intervention involves a standardized stress management for headaches (SMH) group intervention that focuses on stress and general stress management skills, headache symptoms and their management, sleep hygiene, and healthy eating. There will be 8 weekly sessions followed by 4 bi-weekly sessions over a period of 4 months.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Are between 18 and 65 years of age * Report between 4 and 14 headaches over 28 days * Have a history of migraines lasting at least 1 year * Are not currently using opioid (narcotic) pain medication

Exclusion criteria

* Are unable to undergo MRI * Pregnant, lactating, or planning to become pregnant * Current use of opioid medications Inclusion Criteria for Healthy Volunteers (same

Design outcomes

Primary

Measure	Time frame	Description
Change in headache frequency and impact	Baseline, 3, 6, and 12 months	Headache days per 28 days and headache-related disability (HIT-6)
Change in gray matter volume	Baseline, 3, and 6 months	Gray matter volume in the insula, dorsolateral prefrontal cortex, and cingulate
Change in Brain Function	Baseline, 3, and 6 months	Overall activation of the dorsolateral prefrontal cortex and the task-positive cognitive network, and resting state connectivity to the insula

Secondary

Measure	Time frame	Description
Change in headache intensity	Baseline, 3, 6, and 12 months	Change in headache intensity
Change in Brain Structure	Baseline, 3, and 6 months	Gray matter volume and white matter tracts across the whole brain
Change in Whole Brain Function	Baseline, 3, and 6 months	Cognitive-related activity, pain-related activity, and resting state across the whole brain

Countries

United States

Outcome results

None listed