Preload Dependency by Impedance Cardiography After Cardiac Surgery

Noninvasive Assessment of Preload Dependency by Passive Leg Raising Test and Impedance Cardiography Compared to Echocardiographic Measurements After Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02132871

Enrollment

Registered

2014-05-07

Start date

2014-05-31

Completion date

2016-05-31

Last updated

2016-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery With Extracorporeal Circulation

Brief summary

The primary purpose of this study is to investigate wether the measure of stroke volume (SV) variations by impedance cardiography during passive leg raising (PLR) can reliably predict preload dependency after cardiac surgery, in comparison to a reference parameter : velocity time integral (VTI) variation measured by transthoracical echocardiography.

Interventions

DEVICEImpedance cardiography Physioflow ®

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Men or women over 18 years * Affiliated to a social protection * Signed written consent * Informed about the results of the medical visit * All type of cardiac surgery with extracorporeal circulation performed at University Hospital of Strasbourg * Sedated and under mechanical ventilation

Exclusion criteria

* Cardiac arrhythmia * Contraindication to PLR maneuver * Exclusion period due to inclusion in a previous or ongoing study * Impossibility to provide enlightened information * Patient deprived of liberty, under judicial protection, trusteeship or guardianship * Pregnancy, lactation

Design outcomes

Primary

Measure	Time frame	Description
Area under ROC curve comparing SV variation (impedance cardiography) and VTI variation after PLR	Within the 6 first hours after cardiac surgery	Patients classified as responders and non responders to PLR : VTI variation ≥ 12% or \< 12%

Secondary

Measure	Time frame
Respiratory variation of inferior vena cava	Within the 6 first hours after cardiac surgery
Variation of central veinous pressure, left auricular pressure and left ventricular filling pressures after PLR (ROC curves, correlation tests)	Within the 6 first hours after cardiac surgery

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026