Sjogren Syndrome
Conditions
Brief summary
Speckle tracking (STE) is a novel echocardiographic technique which permits calculation of myocardial velocities and deformation parameters such as strain and strain rate (SR). It is demonstrated that these parameters provide important insights into systolic and diastolic function, ischaemia, myocardial mechanics and many other pathophysiological processes of the heart. In this preliminary study, we investigated the role of STE in detection of early ventricular dysfunction in patients with Sjogren Syndrome, focusing on cardiorespiratory fitness.
Interventions
PROCEDURESpeckle tracking echocardiography
Sponsors
University of Roma La Sapienza
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of Sjogren Syndrome
Exclusion criteria
* previous cardiovascular events * unstable angina * stroke * diagnosis of heart failure * incapacity to provide an informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Longitudinal Myocardial Strain reduction in Sjogren Patients | Baseline, 24 weeks | Longitudinal Myocardial Strain reduction could be an early marker of cardiac dysfunction in patients with Sjogren Syndrome, significantly better than common measurement (such as ejection fraction) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association between 6minute-walking-test and Longitudinal strain reduction | baseline, 24 weeks | Longitudinal strain reduction could be linked to decrease in cardiorespiratory fitness, especially in 6-minute-walking-test |
Countries
Italy
Outcome results
None listed