Vertebral Fractures
Conditions
Keywords
HIV, bone, fractures, vitamin D, biomarkers
Brief summary
Prospective cohort study to determine the prevalence of vertebral fractures in HIV infected patients older than 50 years.
Detailed description
To determine the prevalence of asymptomatic vertebral fractures in HIV patients older than 50 years, and the risk of fracture during a follow up of 2 years, according to bone mineral density at inclusion, the level of serum bone biomarkers, and the presence of secondary factors such as hypovitaminosis D or/and secondary hyperparathyroidism.
Interventions
None listed
Sponsors
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age above 50 years * HIV infection
Exclusion criteria
* Pregnancy * Receiving corticosteroids or antiresorptive therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of vertebral fractures in HIV patients older than 50 years | 2 years | To determine by lumbar and thoracic x ray the presence of vertebral fractures and the changes in vertebral form or size, according to Genant methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Risk of vertebral alteration according to bone mineral density and serum biomarkers | 2 years | To determine the relationships of vertebral alterations with bone mineral density by dual X-ray absorptiometry |
| Vertebral alterations during follow up | 2 years | To determine the emergence of vertebral alterations during 2 years of follow up according to bone mineral density, bone biomarkers (osteocalcin, beta-crosslaps), and vitamin D/parathyroid hormone (PTH) status. |
Countries
Spain
Outcome results
None listed