Ageing, Obesity
Conditions
Keywords
Brown adipose Tissue, Ageing, Sympathetic Nervous Stimulation, Obesity
Brief summary
In this study the investigators aim to investigate whether the sympathetic stimulation of BAT, as assessed with a 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scan, differs between young and elderly subjects, as an explanation for the diminished metabolic brown adipose tissue activity in the elderly. The investigators hypothesis is that sympathetic nervous system activity in the elderly is diminished as compared to their younger counterparts as an explanation for the diminished metabolic brown adipose tissue activity in the elderly.
Detailed description
The sympathetic nervous system is the primary activator of Brown Adipose Tissue. Elderly are known to have less metabolically active brown adipose tissue as compared to their younger counterparts. The reason for this diminished metabolic brown adipose tissue activity is unknown. However, a lower sympathetic nervous system activation to brown adipose tissue in the elderly might explain a diminished metabolic brown adipose tissue. Therefore, in this study, both the sympathetic nervous system activation to brown adipose tissue and the metabolic activity will be measured in young and older subjects. sympathetic nervous system activity will be measured using 123I-metaiodobenzylguanidine single-photon emission computed tomography computed tomography scans, metabolic activity will be measured using 18F- fluorodeoxyglucose positron emission tomography CT scans.
Interventions
OTHER18-FDG PET CT scan and 123I-MIBG SPECT scan
Sponsors
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
MALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male * Caucasian origin * Subjects should be able and willing to give informed consent * 18-65 years old * BMI range of 19-27 kg/m2
Exclusion criteria
* Renal failure (creatinine\>135mmol/l) * Daily use of prescription medication * Prior participation in a research protocol involving radiation exposure in the last 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in sympathetic stimulation to BAT between young and older individuals | Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in correlation between sympathetic stimulation of BAT as assessed with 123I-MIBG SPECT scans and metabolic BAT activity as assessed with 18F-Fluorodeoxyglucose(FDG)- positron emission tomography(PET)-CT scan in young and older individuals | Participants will be followed for a mean duration of 2 weeks (the maximal time period between the two scans) The outcome measurements will be assessed when the last subject has been scanned approximately one year after starting the trial. | The difference in correlation between sympathetic stimulation of BAT as assessed with a MIBG SPECT-CT scan, and BAT activity itself as assessed with 18F-FDG-PET-CT, between young and elderly subjects |
Countries
Netherlands
Outcome results
None listed