Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients

Predictive Value of Periodic Repolarization Dynamics in Post-Infarction Patients: Validation Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02128477

Acronym

PRD-MI

Enrollment

754

Registered

2014-05-01

Start date

2010-10-31

Completion date

2016-12-31

Last updated

2017-01-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Keywords

Myocardial infarction, Repolarization instability, Ventricular fibrillation

Brief summary

Increased periodic repolarization dynamics (PRD) indicate increased risk of death in cardiac patients. This study thoughts to prospectively validate the prognostic value of PRD in post-infarction patients.

Detailed description

Periodic repolarization dynamics (PRD) reflect periodic changes of repolarization instability located in the low-frequency spectral range. Level of PRD can be assessed using a high resolution surface ECG recorded in the 12-leads of Frank leads configuration during resting conditions. Increased levels of PRD have been associated with sympathetic overactivity and increased risk of mortality in survivors of acute myocardial infarction and patients undergoing a clinically indicated exercise test.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* previous myocardial infarction \>4 weeks * age \>18 years

Exclusion criteria

* life expectancy \< 1 year due to non-cardiac causes * unable to give informed consent

Design outcomes

Primary

Measure	Time frame
Number of total deaths	24 months

Secondary

Measure	Time frame
Number of cardiovascular deaths	24 months

Countries

Germany

Outcome results