Infertility
Conditions
Keywords
Low ovarian reserve, Poor responder, Infertility
Brief summary
The purpose of this study is to determine whether minimal ovarian stimulation for in vitro fertilization is superior to high dose stimulation. Number of mature eggs, number of embryos as well as pregnancy rates will be compared.
Detailed description
A prospective randomized trial will be carried out. The Minimal stimulation (MS) protocol is based on low dose letrozole 2.5 mg over 5 days, starting from cycle day 2, overlapping with low dose gonadotropins, starting from day 3 of the letrozole at 150 units per day. GnRH antagonist wil be introduced to avoid premature LH surge when one or more of the growing follicles reached approximately 14 mm in size. The high dose stimulation protocol is based on high dose of gonadotropins (≥300 IU/day) throughout the cycle with the usage of gonadotropin-releasing hormone (GnRH) antagonist to avoid premature luteinizing hormone (LH) surge as described above.
Interventions
DRUGLetrozole, Gonadotropins
DRUGGonadotropins
Sponsors
Sheba Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 43 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of poor responder to ovarian stimulation
Exclusion criteria
* Patients undergoing pregestational diagnosis (PGD) * Patients using donor eggs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rates | 1 Year |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of High quality embryos | 1 year | How many embryos of 6-8 cells with low fragmentation in each arm |
| Number of eggs retrieved | 1 year | — |
Countries
Israel
Contacts
Primary ContactShir Dar, MD
Outcome results
None listed