Morbid Obesity, Pulmonary Embolism
Conditions
Keywords
Morbid obesity, Laparoscopic surgery, Compression ultrasonography, Pulmonary embolism, Bleeding
Brief summary
Obese patients undergoing bariatric surgery warrant VTE prophylaxis because they are at high risk for developing a fatal pulmonary embolism or postthrombotic syndrome. However, a consensus does not exist on the most effective prophylactic approach.
Detailed description
Two regimens of prophylaxis are supposed , the 1st one is to give enoxaparin 40mg 2 hours before surgery and continued daily for 10 days after, and the 2nd one is to start 12 hours before surgery and continued in the same way like the 1st one.
Interventions
DRUGEnoxaparin 40 mg 2 hours before arm
Enoxaparin 40 mg 2 hours before surgery
DRUGEnoxaparin 40 mg 12 hours before arm
Enoxaparin 40 mg 12 hours before surgery
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* BMI \>40 OR \>35 with comorbidities
Exclusion criteria
* No
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Venous thrombosis and/or pulmonary embolism (PE) | Postoperative 4 weeks | To assess the venous thrombosis by compression ultrasonography and PE in suspected patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Bleeding from the surgery site , drain if any, GIT bleeding, | postoperative 4 weeks | Bleeding from drain, GIT, or wounds are assessed clinically |
| hospital stay | 4 WEEKS | hospital stay in days |
Countries
Egypt
Contacts
Primary Contactmohamed e abd ellatif, phd
Outcome results
None listed