Infective Endocarditis
Conditions
Keywords
Infective endocarditis, Developing country, Global health, Cardiac surgery, Heart valve disease, Bacteremia
Brief summary
Introduction. Comprehensive data on infective endocarditis in developing countries are scarce. Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis in low-income countries. Methods : Prospective, Observational, Multicentre study. Inclusion criteria: patients aged over 1 year fulfilling the modified Duke criteria for infective endocarditis. Exclusion criteria: patient included during a previous infective endocarditis episode. Outcomes measures: Mortality at 6 months follow-up; mortality at 1 month follow-up; access to antibiotic treatment (modalities and duration), hospital length of stay and reason for discharge, and cardiac surgery when indicated. Duration: One year (June 2014- June 2015)
Interventions
None listed
Sponsors
War Memorial Hospital
Centers for Disease Control and Prevention
Oxford University Hospitals NHS Trust
St. Elizabeth Catholic General Hospital Shisong, Cameroun
CHU de Brazzaville, Congo Brazzaville
Polyclinique International de Bamako, Mali
CHR de Saint-Louis Lt Colonel Mamadou Diouf, Sénégal
Hôpital Général de Grand Yoff de Dakar, Sénégal
Bafoussam Regional Hospital, Cameroon
Hospital Laquinitinie de Douala
Yaounde Central Hospital
National Hospital of Niamey
Centre National Hospitalier Universitaire de Pneumo-Phtisiologie de Cotonou, Benin
Hospital General De Douala
Eduardo Mondlane University
Laos Oxford Mahosot Wellcome Research Unit
Mulago Hospital, Uganda
Fann Hospital, Senegal
Institute of Cardiology Abidjan
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients aged over 1 year diagnosed with infective endocarditis according to the modified Duke criteria
Exclusion criteria
* Already included for a previous episode of infective endocarditis (i.e., relapse or reinfection)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality at 1 month follow-up | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Mortality at 6 months follow-up | 6 months |
Other
| Measure | Time frame | Description |
|---|---|---|
| Access to cardiac surgery | 6 months | Heart surgery is not available in many low-income countries. One of the objectives is to assess whether guidelines can be applied in low-secourced settings. |
Countries
Fiji, Laos, Mozambique, Senegal, Uganda
Outcome results
None listed