Effect of Gabapentin on Pain of the Second Cataract Surgery

The Effect of Pretreated Gabapentin on Hyeralgesia Occurring in the Second Operation in Staged Bilateral Cataract Surgery

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02127853

Enrollment

Registered

2014-05-01

Start date

2014-07-31

Completion date

2016-02-29

Last updated

2015-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyperalgesia

Keywords

serial cataract surgery, hyperalgesia, gabapentin, central sensitization

Brief summary

Gabapentin pretreatment may reduce hyperalgesia occurring at the second surgery in serial, bilateral cataract surgery.

Detailed description

Hyperalgesia occurring at the second operation in bilateral eye surgery is well known, and mechanism of central sensitization might be involved. Gabapentin is known to lower the effect of central sensitization, and its effect on acute postoperative pain has been reported. Therefore, pretreatment of gabapentin after first operation may reduce the pain at second operation.

Interventions

DRUGgabapentin

100 mg tid of gabapentin is prescribed to the patient for 1 week after the first eye surgery

DRUGplacebo

the same regimen of placebo drug is prescribed to the patient for 1 week after the first eye surgery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Patient of ASA(American Cociety of Anesthesiology) class I, II, III between age 20 to 80, scheduled for serial bilateral cataract surgery(1 weel interval)

Exclusion criteria

* refuse to participate * BMI\<16 or BMI \>30 * severe cardiovascular, pulmonary, renal disease * alcohol or drug abuse * currently taking CNS(central nervous system) inhibitory drugs * taking antiacids * depressive disorder pregnancy

Design outcomes

Primary

Measure	Time frame
proportion of subjects who answer that pain was greater in the second eye surgery	Intra operative (pain while fluid injection to anterior chamber)

Secondary

Measure	Time frame	Description
perioperative pain	end of surgery, post-op 1hr at PACU, at out-patient ward, post-op 1 day	evaluation of overall perioperative pain

Other

Measure	Time frame	Description
satisfaction	intra operative	evaluation of satisfaction of both operator and patient
anxiety	baseline (at OR room arrival, just before sterile draping)	evaluation of patient's anxiety

Countries

South Korea

Contacts

Primary ContactHeepyoung Park, MD,PhD

hppark@snu.ac.kr82-2-2072-2466

Backup ContactEugene Kim, MD

tomomie@hanmail.net82-2-2072-2469

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026