Haptoglobin Type
Conditions
Brief summary
Intra Uterine Growth Restriction is associated with increased oxidative stress. Haptoglobin (Hp) is an abundant plasma glycoprotein produced in the liver. The function of Hp is as anti oxidant agent, it binds free hemoglobin (Hb) released from red blood cells to decrease oxidative tissue damage. There are 3 differenet genotype of haptoglobin Hp 1-1 Hp 1-2 and Hp 2-2 with different anti oxidant properties and different prevalence ( Hp 1-1, Hp 1-2 and Hp 2-2approximately 16%, 48% and 36% respectively) . we hypotheise that IUGR will be more common and severe in the Hp 2-2 genotype with the less anti oxidant properties.
Interventions
None listed
Sponsors
Hillel Yaffe Medical Center
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
Pregnancies complicated with IUGR -
Exclusion criteria
NOT INTERESTED DO PARTICIPATE \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| type of haptoglobin | 10 weeks | severity of iugr |
Outcome results
None listed