Carbon Dioxide Pressure, Endothelial Dysfunction, FMD, Forced Expiratory Volume After 1 Second, IMT, Microcirculation, Oxygen Pressure, Oxygen Saturation
Conditions
Keywords
chronic obstructive pulmonary disease, Coronary artery disease, Endothelial function
Brief summary
Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular. Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging. We hypothesize that hypoxemia leads to impaired vascular function.
Interventions
None listed
Sponsors
Klinik für Kardiologie, Pneumologie und Angiologie
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
MALE
Age
40 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* stable coronary artery disease * stable chronic obstructive pulmonary disease
Exclusion criteria
* acute myocardial infarction within 30 days * acute exacerbated COPD within 30 days * acute infections * severe acute or chronic renal failure * severe heart failure * atrial fibrillation * severe cardiac arrhythmia * hypotension * active malignant disease * active rheumatic disease * pulmonary hypertension with vasoactive therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flow-mediated dilation of the brachial artery | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Endothelium-independent vasodilation of the brachial artery | Baseline |
| Forearm blood flow | Baseline |
| Intima-media thickness of the brachial artery | Baseline |
| Fractional diameter change of the brachial artery | Baseline |
| Laser doppler perfusion | Baseline |
Other
| Measure | Time frame |
|---|---|
| Plasma nitrite concentration | Baseline |
Countries
Germany
Outcome results
None listed