Rapid Medical Donation Programme for Breast Cancer

Rapid Medical Donation Programme for Breast Cancer to Examine Tumour Heterogeneity

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02126800

Acronym

LEGACY

Enrollment

Registered

2014-04-30

Start date

2014-03-31

Completion date

2019-03-31

Last updated

2014-04-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metastatic Breast Cancer

Keywords

breast cancer

Brief summary

Treatment of breast cancer has traditionally been based on the primary tumour's features in the breast. Only recently, when cancer returns at other sites, has there been an attempt to biopsy the metastatic disease and change treatments accordingly. A 'repeat biopsy' can be technically difficult, painful and, when possible, only represents a small sample of one of many metastases. Even when one deposit responds to a new treatment, a neighbouring one may continue to grow. There is an urgent need to characterise all deposits, particularly the lethal ones which progress despite all treatments. This study will enable the comprehensive analysis of the metastatic process and the evolution of the breast cancer through the course of its treatment. Patients who have consented during life to donate their tissues for molecular analysis will provide the means for such an analysis. Main aims: * To comprehensively and systematically examine metastatic breast cancer by its detailed exploratory molecular characterization to elucidate the possible inter- and intratumoural heterogeneity between the primary tumour and the majority of metastatic sites. * To map the natural history of the metastatic breast cancer process

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who have completed active treatment (or trials) for metastatic breast cancer. * Patients referred to either community or the hospital-based palliative care unit from Royal Marsden National Health Service Foundation Trust.

Exclusion criteria

* Lack of capacity / inability to give informed consent. * Diagnosis of alternative cancer within the last 5 years other than resected basal cell skin cancer or cervical intraepithelial neoplasia. * Patients known to be HIV, Hepatitis B virus or Hepatitis C virus positive on serology . * Spongiform encephalopathy (known or suspected CJD) . * Eligibility for or current participation in a clinical trial (excluding palliative care trials)

Design outcomes

Primary

Measure	Time frame
The acquisition of tumour tissue from multiple metastatic sites.	Within 6 hours from the time of death.

Countries

United Kingdom

Contacts

Primary ContactSally Bennett, RN

LEGACY-BC@icr.ac.uk+44 (0)2073528171

Outcome results