Comparing Weaning of Nasal Continuous Positive Airway Pressure (CPAP) From Preterm Infants

Randomized Control Trial of Weaning NCPAP From Preterm Infants: Sudden Wean Versus Weaning by Gradually Decreasing Pressure

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02126501

Enrollment

Registered

2014-04-30

Start date

2013-12-31

Completion date

2015-12-31

Last updated

2016-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Distress Syndrome

Keywords

weaning, NCPAP, Preterm, sudden wean, gradual pressure off wean

Brief summary

To compare the 2 methods of weaning of nasal continuous positive airway pressure (CPAP) in premature babies born between 26 and 32 weeks

Detailed description

To study the weight and the post menstrual age (PMA) at the time of NCPAP wean utilizing the method of sudden wean as compared to gradual wean. Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age between 26 and 32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared

Interventions

OTHERGradual pressure wean

NCPAP will be removed by gradually decreasing pressure over 24 hours once the weaning is decided

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

26 Weeks to 32 Weeks

Healthy volunteers

Inclusion criteria

* All neonates born 26 to 32 weeks of gestational age

Exclusion criteria

* Those with severe congenital anomalies and chromosomal defects including congenital heart disease, neurological malformations, chest and airway abnormalities and lung hypoplasia

Design outcomes

Primary

Measure	Time frame
Success of weaning on first trial off NCPAP	Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks

Secondary

Measure	Time frame
Weight and corrected GA when come off oxygen	when off supplemental oxygen expected average of 2 weeks
Weight and corrected gestational age (GA) when neonates could come off NCPAP	Completion of Nasal Continuous Positive Airway Pressure (NCPAP) treatment, expected average of 4 weeks

Other

Measure	Time frame
length of stay in the neonatal intensive care unit	when ready to be discharged, expected average of 6-8 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026