Periodontal Disease, Chronic Periodontitis
Conditions
Keywords
periodontal disease, therapy, anti-bacterial agents, Randomized Controlled Trials
Brief summary
Evaluate and compare the effectiveness in a clinical and microbial perspective one stage full-mouth disinfection technique in relation to scaling and root planing per quadrant associated with chlorhexidine or azithromycin.
Detailed description
Seventy -seven systemically healthy subjects with chronic periodontitis were randomly included in 6 different predefined groups. The following periodontal parameters were evaluated: probing depth , clinical attachment level , plaque index, gingival index and percentage of areas affected by periodontal disease. Microbiologically were evaluated the bacterial load and specific load of five bacterias: The quantification of the bacteria was performed by real-time Polymerase Chain Reaction . The clinical and microbial baseline evaluations were performed ( periodontal pre- therapy) , 90 and 180 days after treatment.
Interventions
PROCEDUREScaling and root planing
Scaling procedures were performed per quadrant (30 min. per quadrant) at weekly intervals between sessions;
PROCEDUREFull mouth disinfection
Procedures for scaling and root planing were performed in a single stage (24 hours) divided into two sessions (60 min per session) on two consecutive days
DRUGChlorhexidine gel and gluconate
application of chlorhexidine (CX) (1%) gel in pockets after scaling, brushing tongue for 1 min. with CX (1%) gel and mouthwash at the beginning and end of each session with CX 0.2% for 30 seconds (with the form of a gargle in the last 10 seconds)
Home use fo CX 0.2% for 60 consecutive days after the end of the first session of scaling.
DRUGAzithromycin
Azithromycin (500 mg) once daily for 3 consecutive days.
Sponsors
Federal University of Minas Gerais
Centro Universitario de Lavras
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of slight-moderate chronic periodontitis
Exclusion criteria
* Those who were making regular use of antibiotics or anti-inflammatory drugs or had done up to three months before the beginning of the study; * those who were making regular use (twice a day) of oral rinses with chlorhexidine or essential oils or have made regular use within three months prior to study entry; * individuals with a history of sensitivity to chlorhexidine or azithromycin; * subjects undergoing periodontal therapy include dental scaling procedures in the 12 months preceding the start of the study; * subjects with impaired bifurcation or trifurcation class III; * who required antibiotic prophylaxis for conducting clinical periodontal examination * subjects with removable partial dentures and removable or fixed orthodontic appliance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in clinical attachment | Baseline and 180 days after treatment | In this parameter we will evaluate the distance from the cement-enamel junction to the bottom of the periodontal pocket or gingival sulcus. This measurement is made with a periodontal probe graduated in millimeters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in probing depth | Baseline and 180 days after treatment | In this parameter we will evaluate the distance between the gingival margin and the bottom of the periodontal pocket or gingival sulcus. This measurement is made with a periodontal probe graduated in millimeters |
Countries
Brazil
Outcome results
None listed