The Princess Alexandra Hospital and the QIMR Berghofer Medical Research Institute Head and Neck Cancer Study

An Epidemiological Study of Mucosal Squamous Cell Carcinomas of the Head and Neck

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02126189

Enrollment

600

Registered

2014-04-29

Start date

2013-11-30

Completion date

2016-11-30

Last updated

2015-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Squamous Cell Carcinoma, Human Papillomavirus

Keywords

Head and Neck Squamous Cell Carcinoma, Human Papillomavirus, Aetiology, prevalence, risk factors, clinical outcome

Brief summary

This study is designed to refine the aetiological causes of cancers of the head and neck and investigate the ways in which human papillomavirus and life-style factors cause head and neck cancers. This study will determine if these factors affect the treatment of cancer. All patients attending the Head and Neck Clinic at the Princess Alexandra Hospital is invited to complete a risk factor questionnaire and give consent for their clinical data and tissue samples to be available for future research activities. The risk factor questionnaire is based on existing validated instruments developed by the QIMR Berghofer Medical Research Institute Cancer Control Group, and will collect standardised information relating to demographics and causal factors (tobacco and alcohol intake), risk modifiers (dentition, asprin and non-steroidal anti-inflammatory drugs (NSAIDS), height, weight, physical activity, diet quality etc) and behaviours (oral sex etc)

Detailed description

Data is collected using a simple four-page paper-based questionnaire. Information to be collected include age, sex, height and weight (at age 20, current age, and heaviest ever), history of cancer (own and partner). Questions about recreational physical activity, smoking history and alcohol consumption, acid reflux, heartburn, denture use and tonsillectomy, frequency of use of paracetamol, antihistamine and NSAIDS. The questionnaires also ask participants some detailed questions about sexual behaviour and history if they are comfortable to give this information.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* All patients presenting to the Head and Neck Cancer Clinic at the Princess Alexandra Hospital Brisbane Australia.

Exclusion criteria

* nil

Design outcomes

Primary

Measure	Time frame
To identify exposures associated with an increased risk of head and neck squamous cell carcinoma	2 years

Other

Measure	Time frame
To compare subjects who have ever been exposed with those who have never been exposed.	2 years
To estimate the effect of each exposure adjusted for the confounding effects of other exposures.	2 years
To test for trends in head and neck squamous cell carcinoma	2 years

Countries

Australia

Contacts

Primary ContactDana Middleton

dana.middleton@health.qld.gov.au61 7 3176 3219

Outcome results