Lung Diseases, Interstitial, Pulmonary Disease, Chronic Obstructive
Conditions
Brief summary
The objective is to study the cognitive functions in patients with chronic obstructive lung disease (COLD) and patients with interstitial lung disease (ILD) compared to healthy controls. The cognitive functions are tested with and without oxygen therapy to clarify the effect of oxygen therapy. Driving simulations is used to test the cognitive functions. The hypothesis is that patients with chronic lung disease have decreased cognitive functions and that oxygen therapy will increase their cognitive functions.
Interventions
OTHERoxygen therapy
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* COLD with forced expiratory volume at one second (FEV1) \<50%, without long term oxygen therapy * COLD with FEV1 \<50%, with long term oxygen therapy * ILD with diffusion capacity of lung for carbon monoxide (DLCO) \< 50%, without long term oxygen therapy
Exclusion criteria
* comorbidity which decreases cognitive function * comorbidity which decreases concentration * physical comorbidity which makes it impossible to complete the test
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Standard deviation from the centre of the road | During the 45 min. of driving in the simulator | Measuring how far from the centre of the road the patient has been driving in the driving simulation |
| Number of nil responses | During the 45 min. of driving in the simulator | Measuring the number of times the patients doesn't react to the number 2 on the screen |
| Response time | During the 45 min. of driving in the simulator | Measuring the mean amount of response time from the number 2 appears on the screen until the patient reacts |
| Number of off-road events per hour | During the 45 min. of driving in the simulator | The number of times the car is off-road during the driving simulation |
Countries
Denmark
Outcome results
None listed