Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis

Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02125812

Enrollment

Registered

2014-04-29

Start date

2011-08-31

Completion date

2014-04-30

Last updated

2014-06-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggressive Periodontitis

Keywords

Aggressive Periodontitis, antimicrobial(s), microbiology

Brief summary

The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive Periodontitis. The overall objective of this study is to evaluate the clinical and microbiological efficacy of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing over placebo in the treatment of aggressive periodontitis.

Interventions

OTHERscaling and systemic moxifloxacin

scaling and root planing (SRP) combined with systemic moxifloxacin

OTHERscaling and root planing

scaling and root planing

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

15 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* under 30 years old and systemically healthy, with at least 20 teeth present. Be willing to participate in the study which is corroborated by signing the informed consent form. Commit to attend post-therapeutic controls and stop drinking alcohol during the time of ingestion of antibiotics.

Exclusion criteria

* Subjects in whom are contraindicated or with hypersensitivity to quinolones - Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy six months before the start of the study according to interrogation. Women in pregnancy or lactation, corroborated with previous medical history and medical consultation.

Design outcomes

Primary

Measure	Time frame
probing depth	six months

Secondary

Measure	Time frame
clinical attachment level and probing depth	6 moths

Countries

Colombia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026