Living Donor Liver Transplantation in Children

Living Donor Liver Transplantation in Children: Surgical and Immunological Results in 250 Recipients at Université Catholique de Louvain.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02124382

Enrollment

500

Registered

2014-04-28

Start date

2012-03-31

Completion date

2014-03-31

Last updated

2014-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Donors, Pediatric Liver Transplanted Recipients

Keywords

liver failure, liver malignancy, metabolic diseases, Pediatric liver transplanted recipients and their healthy donors

Brief summary

Evaluate the outcome of pediatric living donor liver transplantation (LDLT) regarding portal vein reconstruction, ABO-compatibility and impact of maternal donation on graft acceptance.

Detailed description

Data from 250 pediatric LDLT recipients (and their donors), transplanted at Cliniques universitaires Saint-Luc between July 1993 and June 2012, were collected retrospectively using electronic data files. Results were analysed according to ABO matching and portal vein complications. Uni- and multi-variate analysis was used to study the impact of immunosuppression, gender match and maternal donation on acute rejection rate.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 57 Years

Healthy volunteers

Yes

Inclusion criteria

* Children receiving a living donor liver transplant * Adult living donors

Exclusion criteria

* No one

Design outcomes

Primary

Measure	Time frame	Description
Patient and graft survival	10 years	Kaplan-Meier

Secondary

Measure	Time frame
Portal vein complications	10 years

Other

Measure	Time frame
Graft rejection free survival	10 years

Outcome results