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Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy

Treatment Strategy in Patients With High-risk of Postextubation Distress in ICU Based on a Lung Ultrasound Score Versus Standard Strategy

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02123940
Acronym
WIN IN WEAN
Enrollment
483
Registered
2014-04-28
Start date
2014-02-28
Completion date
2018-08-25
Last updated
2019-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Patients Ventilated More Than 48 h

Keywords

Weaning from mechanical ventilation, Lung ultrasound, Nasal humidified high flow therapy, Weaning failure, Postextubation distress

Brief summary

Prospective, randomized clinical multicentric study in ICU during weaning from mechanical ventilation.

Detailed description

Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy

Interventions

DEVICElung ultrasound score

Prospective randomized clinical multicentric study on ICU comparing a treatment strategy (nasal humidified high flow therapy and Noninvasive Ventilation) in patients with high-risk of postextubation distress in ICU based on a Lung Ultrasound Score VERSUS standard strategy

Sponsors

Pitié-Salpêtrière Hospital
CollaboratorOTHER
University Hospital, Grenoble
CollaboratorOTHER
Hospices Civils de Lyon
CollaboratorOTHER
Centre Hospitalier Universitaire de Saint Etienne
CollaboratorOTHER
University Hospital, Marseille
CollaboratorOTHER
University Hospital, Clermont-Ferrand
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adult patients ventilated more than 48 h * Stable respiratory and hemodynamic conditions for SBT * Consent of patients * Arterial line

Exclusion criteria

* severe COBP * Laryngeal dyspnea * Tracheostomy * Arrhythmia * No echogenicity * Paraplegia \>T8

Design outcomes

Primary

MeasureTime frameDescription
Incidence of postextubation distressduring 48 hour (at day 1)postextubation period requiring a ventilatory support (reintubation or curative Noninvasive ventilation).

Secondary

MeasureTime frameDescription
Length of stay in ICUat day 1—
Mortality in ICUat day 1—
Extubation failureat day 7Extubation failure within the 7 days following planned extubation
Number of ventilator-free-daysat day 1 (after extubation)—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026