Lung Cancer, Pulmonary Disease
Conditions
Keywords
Lung cancer, pulmonary disease
Brief summary
Use of a microfabricated silicon device to concentrate ultra trace volatile organic compounds (VOCs) in human exhaled breath for quantitative analysis of VOCs.
Detailed description
Will use Fourier Transform Mass Spectrometry (FT-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) to analyze concentrated VOCs. The purpose of this study is to search for disease-related markers in the breath in subjects with known or suspected lung or other cancer, or pulmonary disease.
Interventions
None listed
Sponsors
James Graham Brown Cancer Center
University of Louisville
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* For controlled (healthy) subjects - we are seeking persons who do not have a known history of cancer or pulmonary disease. * Both smokers and nonsmokers are invited to participate as control subjects. * For experimental subjects, we are seeking persons with pulmonary disease but no known history of cancer, as identified by the investigators during routine clinic or office visits. * Additionally for experimental subjects, we are seeking persons with known or suspected lung or other cancers, as identified by the investigators during routine clinic or office visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Detection of disease related markers (biomarkers) from concentrated volatile organic compounds in breath samples | 1 day (After sample collection) | The concentrated volatile organic compounds in exhaled breath samples will be analyzed by statistical software for search for disease related markers (biomarkers). |
Countries
United States
Outcome results
None listed