Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02122276

Enrollment

Registered

2014-04-24

Start date

2010-01-31

Completion date

2012-01-31

Last updated

2014-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Cord Injury(SCI)

Keywords

Spinal cord injury, Passive motion, Fatigue index, Hypertonia

Brief summary

In animal and human studies, histochemical and physiological evidences showed that the muscle transferred from slow, fatigue-resistant muscle to fast, fatigable muscle after spinal cord injury. The alternation of muscular property was accompanied by the alternation of spinal circuitry property, and was related to the immobilization adaptation. Previous study showed that remobilization by continuous passive motion (CPM) for one month would restore the function of spinal circuitry in individual with chronic SCI. It is possible that long term application of CPM can reverse the adaptation of contractile properties of the paralyzed muscle after SCI. The purpose of this study is to investigate the effect of a four month CPM training on muscular properties in individuals with chronic SCI.

Interventions

PROCEDUREAnkle continuous passive motion machine.

A rehabilitation program of machine driven passive stretch exercise on ankle.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of complete spinal cord injury

Design outcomes

Primary

Measure	Time frame	Description
The contractile properties of the muscles	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in contractile properties of soleus and tibialis anterior
Fatigue index	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in Fatigue index of soleus and tibialis anterior.
Clinical muscle tone tests	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in clinical muscle tone tests of soleus and tibialis anterior by Modified Ashworth Scale.
Patient Reported Impact of Spasticity Measure (PRISM)	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in PRISM.
The potential adverse effects of ankle swelling	Baseline, 1 month, 2 months, 3 months, and 4 months	Measure of changes in the potential adverse effects of ankle swelling.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026