Breast Cancer Survivors
Conditions
Keywords
Treatment Exposure, Smoking History, 14-071
Brief summary
In this study,the investigators are looking to see how older women who are survivors of breast cancer and either did or did not receive chemotherapy are affected by treatment, compared to older women who have never had cancer. Thinking and memory abilities normally decrease with age and the investigators want to see if the long-term effects of cancer treatments may make these problems worse. The investigators will also look at how thinking and memory abilities of older women are affected by genetics and smoking history. Genetics and other factors may affect the brain's chemicals or structure, and may either protect against the negative effects on thinking or make someone more at risk for them. MSK participants who previously consented to allostatic blood and saliva collection but have not yet provided any allostatic blood or saliva samples for this study, will not be asked to provide any further samples at follow-up. Participants who have consented to allostatic sample collection and provided one set of allostatic blood and saliva samples at a previous follow-up study visit will still be asked to provide a second set of samples at a later follow-up. COH participants will continue to provide allostatic blood and saliva collection as originally outlined
Interventions
None listed
Sponsors
Memorial Sloan Kettering Cancer Center
City of Hope Medical Center
The New School for Social Research
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
60 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* The neuropsychological assessments were designed and validated in English and are not currently available in other languages. Translation of questionnaires into other languages would require reestablishing the reliability and validity of these measures. Therefore, participants must be able to communicate in English to complete the tests. Friend nominated, non-cancer controls will be frequency matched on age (+/- 5 years), education (less than college vs. some college and above), and race will be recruited using the same eligibility criteria as survivors except for no history of cancer. For cancer patients, eligibility includes: * As per medical record or self-report, post-menopausal female * As per medical record or self-report, age 60 or older at recruitment * As per medical record or self-report, age 55 or older at the time of breast cancer diagnosis * As per medical record or self report, for cancers other than breast cancer or non-melanoma/basal cell skin cancer/squamous cell skin cancer: * Patient must be at least 3 years post diagnosis of that cancer * Not received chemotherapy treatment or external beam radiation for that cancer * As per medical record or self-report, 5-15 years post diagnosis of breast cancer at the time of enrollment * As per medical record or self-report, no evidence of any cancer disease * American Joint Committee on Cancer (AJCC) stages 0-III breast cancer survivor as per clinical judgment/electronic medical record (EMR) * Score of \< 11 on the Blessed Orientation-Memory-Concentration Test (BOMC) * In the judgment of the consenting professional, able to communicate well enough in English through verbal and written communication to complete the study assessments and provide informed consent * English proficiency verified through an adapted Bidimensional acculturation scale, score of 2.5 or above \*\*\*The scale will only be administered to participants who report also speaking a language other than English. For controls participants, eligibility includes: * As per medical record or self-report, post-menopausal female * As per medical record or self-report, age 60 and older at recruitment * In the judgment of the consenting professional, able to communicate well enough in English through verbal and written communication to complete the study assessments and provide informed consent °English proficiency verified through an adapted Bidimensional acculturation scale, score of 2.5 or above. \*\*\*The scale will only be administered to participants who report also speaking a language other than English. * Score of \< 11 on the Blessed Orientation-Memory-Concentration Test (BOMC) * As per self report, no history of treatment with chemotherapy * As per self report no history of cancer except non-melanoma/basal cell skin cancer squamous cell skin carcinoma
Exclusion criteria
* For cancer patients,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neurocognitive outcomes | up to 24 months | Neurocognitive tests will be performed longitudinally at 4 time points, enrollment, and 8, 16, and 24 months post enrollment.The participant will also be asked to complete two surveys. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORJames Root, PhD
Memorial Sloan Kettering Cancer Center
Outcome results
None listed