Three Wall Intrabony Defects in Chronic Periodontitis
Conditions
Brief summary
The purpose of the present study was to investigate the efficacy of autologous Platelet rich fibrin (PRF) or PRF and Simvastatin (SMV) with open flap debridement (OFD) in the treatment of three wall intrabony defects in comparison to OFD alone.
Detailed description
90 systemically healthy subjects were divided randomly into three groups (30 subjects in each group, per subject one site). Control group consisted of the sites treated with OFD and test groups sites were treated with OFD with autologous PRF or PRF with SMV. Site-specific plaque index (PI), sulcus bleeding index (mSBI), probing depth (PD), relative attachment level (RAL) and intrabony defect (IBD) depth reduction was measured at baseline and 9 month after surgery.
Interventions
DRUGPlatelet rich fibrin and simvastatin
Three wall intrabony defect sites treated with Open Flap Debridement. 0.1 mL prepared SMV gel (1.2 mg/0.1 mL) was mixed with PRF. The PRF - SMV mixture was delivered to the defect.
BIOLOGICALPlatelet rich fibrin
Three wall intrabony defect sites treated with Open Flap Debridement. PRF was placed into the intrabony defect.
PROCEDUREOpen Flap Debridement alone
Three wall intrabony defect sites treated with Open Flap Debridement only. No PRF or SMV was delivered to the defect.
Sponsors
Government Dental College and Research Institute, Bangalore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects with the diagnosis of chronic periodontitis * presence of three walled intrabony defects (IBD) ≥ 3 mm deep (distance between alveolar crest and base of the defect on intraoral periapical radiograph \[IOPA\]) * interproximal probing depth (PD) ≥ 5 mm following scaling and root planing (SRP) in asymptomatic tooth
Exclusion criteria
* Subjects, with the diagnosis of aggressive periodontitis, * with known systemic illness and taking medications known to affect the outcomes of periodontal therapy * insufficient platelet count (\< 200,000/mm3), * pregnancy / lactation * use of any form of tobacco * unacceptable oral hygiene (if plaque index \[PI\] (Silness & Loe 1964) \>1.5) after the reevaluation of phase I therapy * teeth with furcation defects * non-vital * mobility of tooth ≥ Grade II
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of the study was defect depth reduction evaluated radiographically | At baseline and 9 month after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Relative Attachment Level | At baseline and 9 month after syrgery |
| modified Sulcul Bleeding Index | At baseline and 9 month after surgery |
| Plaque Index | At baseline and 9 month after surgery |
| Probing Depth | At baseline and 9 month after surgery |
Countries
India
Outcome results
None listed