Stroke
Conditions
Keywords
Stroke, Flywheel resistance exercise, Muscle function, Cognitive function
Brief summary
Forty patients will be assigned to either a training group (12 wk unilateral knee extension flywheel resistance exercise; 4 sets of 7 reps 2 days/week) or a control group. Patients will maintain daily routines and any prescribed rehabilitation program. Established methods to assess muscle and cognitive function will be employed before and after the intervention. This project will disclose whether an exercise paradigm, known to improve muscle function and increase muscle volume in healthy populations, will induce similar adaptations in chronic stroke patients. More importantly, this study will elucidate if any impairment in cognitive function caused by stroke, can be reversed with this particular resistance exercise regimen. The information gained from this project will have significant implications and aid in advancing rehabilitation programs and exercise prescriptions for men and women suffering from stroke. The overall objective of this research is to promote independence and hence quality of life in these patients.
Interventions
OTHERFlywheel leg-press resistance exercise
Sponsors
Corporacion Parc Tauli
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mild-moderate hemiparetic gait * \> 6 months post-stroke * Able to perform flywheel leg-press exercise
Exclusion criteria
* Unstable angina * Congestive heart failure * Severe arterial disease * Major depression * Dementia * Chronic pain * Psychotic alterations
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Cognitive Function at 3 months | Baseline, Month 3 | Cognitive function will be assessed before and after the training period in all participants. In a 60-90 min session, with 10 min of rest is needed, validated tests will be used to evaluate different domains of cognitive function: Speed of information processing; Short- and long-term memory; Attention; Language; Learning; Delayed recall; Working memory; Inhibition; Visuo-motor scanning; Dual task attention; Quality of life. |
| Change from baseline in Functional Performance at 3 months | Baseline, Month 3 | Up-and-Go, Fast Gait Speed, Berg Balance Scale |
| Change from baseline in Muscle Function at 3 months | Baseline, Month 3 | Isometric and dynamic force, and peak power during flywheel leg-press exercise. Quadriceps muscle volume (MRI). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Spasticity at 3 months | Baseline, Month 3 | Modified Ashworth Scale |
Countries
Spain
Outcome results
None listed