Pregabalin Compared to Gabapentin for Pain Control in Lumbar Disc Surgery

Gabapentin vs. Pregabalin for Post Operative Pain in Lumbar Microdiscectomy: a Randomized Controlled Trial.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02120703

Enrollment

Registered

2014-04-23

Start date

2011-02-28

Completion date

2011-10-31

Last updated

2014-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intervertebral Disc Prolapse

Keywords

Pregabalin, gabapentin, microdiscectomy, pain

Brief summary

Pregabalin is claimed to have superior analgesic effect at lower doses and better pharmacological profile as compared to gabapentin esp. in perioperative pain control after major surgeries like intervertebral disc surgery. The investigators found that pregabalin is equivalent to gabapentin for relief of post-operative pain at a lower dose in patients undergoing intervertebral disc surgery.

Interventions

DRUGPregabalin

Pregablin 75 mg per oral two times a day

DRUGGabapentin

Gabapentin 200 mg twice daily per oral

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 60 Years

Healthy volunteers

Inclusion criteria

* 30-60 years age * Any gender * elective micro discectomy for intervertebral disc prolapse

Exclusion criteria

1. micro discectomy at two or more vertebral levels, 2. Instrumentation i.e. pedicle screw fixation, hooks etc., 3. history of steroids or alcohol use, 4. Multiple co-morbids i.e. renal failure, chronic liver disease, 5. use of anticonvulsant drugs, 6. Spinal deformity, 7. Obesity (BMI \>30), 8) inability to understand and respond VAS and 9\) patients with known allergy to GABA analogues.

Design outcomes

Primary

Measure	Time frame	Description
Pain	7 days	Pain measurement using Visual Analogue Score at 24 hours and 7th day of surgery

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026