Aphasia, Stroke
Conditions
Keywords
stroke, aphasia, rTMS, Functional MRI, Speech training
Brief summary
The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear. It is hypothesized that the rTMS was associated with increased synaptic connection and neural regeneration which can be evaluated via functional neuroimage and neurofiber imaging analysis. The effect of rTMS intervention was monitored by clinical testing and neuroimaging study.
Detailed description
2-week rTMS modulation has been proved to produce substantial clinical benefit with sham-controlled study. This trial aimed to investigate the possible mechanism and make clinical correlation.
Interventions
DEVICErTMS
To test the efficacy of this specific setting.
Sponsors
vghtpe user
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
25 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Aphasic stroke in chronic stage (over 3 months)
Exclusion criteria
* No seizure history, no brain surgery history, no electronic device in brain or chest, no dementia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concise Chinese Aphasia Test | Before the rTMS intervention, at 2nd week, and 3rd month | Assess the linguistic skills such as conversation, expression, description, comprehension... |
Secondary
| Measure | Time frame |
|---|---|
| Functional MRI | Before rTMS intervention, and at the day completing the rTMS treatment. |
Countries
Taiwan
Contacts
Primary ContactPo-Yi Tsai, MD
Outcome results
None listed