PLATELET RICH FIBRIN COMBINED WITH 1.2% ATORVASTATIN FOR TREATMENT OF INTRABONY DEFECTS IN CHRONIC PERIODONTITIS

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02119520

Enrollment

Registered

2014-04-21

Start date

2013-02-28

Completion date

2014-02-28

Last updated

2014-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Keywords

Periodontitis, Surgery, Growth Factors, Statins

Brief summary

Current study was designed to evaluate the combined efficacy of PRF and 1.2% ATV gel with open flap debridement (OFD) in treatment of intrabony defects in chronic periodontitis subjects.

Interventions

DRUGPlatelet rich fibrin +Atorvastatin

DRUGPlatelet rich fibrin

PROCEDUREopen flap debridement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

25 Years to 45 Years

Healthy volunteers

Inclusion criteria

the presence of 3- wall IBD ≥3 mm deep (distance between alveolar crest and base of the defect on an intraoral periapical radiograph \[IOPA\]) along with an interproximal probing depth (PD) ≥5 mm after phase I therapy (scaling and root planing \[SRP\]) in asymptomatic teeth.

Exclusion criteria

1\) Agressive Periodontitis subjects; 2) Systemic conditions known to affect the periodontal status; 3) medications known to affect the outcomes of periodontal therapy; 4) Hematological disorders and insufficient platelet count (\<200,000/mm3); 5) pregnancy/lactation; and 6) Smoking and tobacco use in any form 7) Immunocompromised individuals.

Design outcomes

Primary

Measure	Time frame	Description
Percentage radiographic defect depth reduction	9 months from baseline	Defect depth reduction will be assessed from baseline to 9 month post operatively on radiographs

Secondary

Measure	Time frame	Description
change in probing depth	9 months from baseline	probing depth will be assessed from gingival margin to pocket depth at baseline and 9 months postoperatively
change in relative attachment level	9 months from baseline	RAL will be assesed from fixed point on the stent at baseline and 9 months postoperatively
change in plaque levels	9 months from baseline	plaque levels were assessed at baseline and 9 months postoperatively
change in gingival bleeding	9 months from baseline	gingival bleeding was assesed at baseline and 9 months postoperatively
change in gingival margin levels	9 months from baseline	change in gingival margin levels were assesed at baseline and 9 months

Countries

India

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026