Micronutrient Supplementation and Incidence of Common Cold

Influence of Micronutrient Supplementation on Duty Days Lost Due to Flu/Common Cold, Immune System, Oxidative Stress and Wellbeing in a Cohort of Middle Management Employees

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02119143

Enrollment

Registered

2014-04-21

Start date

2014-04-30

Completion date

2017-02-28

Last updated

2017-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Immune System Diseases

Keywords

common cold, immunity, oxidative stress

Brief summary

This study investigates the effects of a dietary supplement - a cocktail of vitamins and minerals - on the incidence of common cold in a cohort of middle management employees.The primary outcome is defined as the number of duty days lost due to common cold/flu. Further, immune parameters and markers of redox biology/oxidative stress will be determined. The wellbeing in the cohort will be evaluated via questionnaires.

Detailed description

randomized, double-blinded, placebo controlled trial 82 Subjects, men and women, 25 - 50 yrs, non-smokers, employees of middle management, 24 weeks of supplementation/placebo, 4 wk wash-out of all supplements and dietetic products, undersupply of fruit, vegetables (\< 4 portions/day) and whole grain food (\< 5x/wk)

Interventions

DIETARY_SUPPLEMENTvitamines and minerals

given for 24 weeks, after 4 week wash out of all supplements and dietetic products

DIETARY_SUPPLEMENTplacebo

given for 24 weeks, after 4 weeks wash out of all supplements and dietetic products

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* pre or peri-menopausal * non-smokers * sedentary or moderately trained * BMI: \>20 and \< 35kg/m2 * undersupply of fruits, vegetables and whole grain food, fibres * contraceptives * wash-out

Exclusion criteria

* post-menopausal * smokers * trained people * BMI out of inclusion range * adequate intake of vegetables, fruits and whole grain food, fibres * no adherence to wash-out

Design outcomes

Primary

Measure	Time frame	Description
Incidence of common cold	24 weeks	vitamins and minerals might influence the incidence of common cold in middle aged management employees

Secondary

Measure	Time frame	Description
change in immune markers	24 weeks	cytokine levels and expression of cytokine receptors in leucocytes may change over time due to micronutrient intervention

Other

Measure	Time frame	Description
change in redox biology	24 weeks	micronutrients may influence redox biology of subjects

Countries

Austria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026