Dehydration, Rehydration, and Blood Viscosity

Randomized, Double-blind, Parallel Arm Study of the Effect of Essentia Water, an Electrolyzed High-pH Bottled Water, on Serial Blood Viscosity and Other Hydration Biomarkers in Healthy Subjects

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02118883

Enrollment

100

Registered

2014-04-21

Start date

2014-04-30

Completion date

2014-07-31

Last updated

2014-07-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dehydration

Keywords

exercise, hydration, dehydration, rehydration, alkaline water, blood viscosity, plasma osmolality, bioimpedance

Brief summary

The purpose of this study is to examine and compare the rehydration effect of Essentia Water, an electrolyzed high-pH bottled water, with industry-standard bottled water purified by reverse osmosis with minerals added, on (1) whole blood viscosity, (2) plasma osmolality, (3) bioelectrical impedance analysis, and (4) body mass change, using serial measurements in apparently healthy adults following exercise-induced dehydration in a controlled environment.

Interventions

OTHEREssentia Water

OTHERBottled water

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

25 Years to 49 Years

Healthy volunteers

Yes

Inclusion criteria

* Free from any medication for at least 1 week prior to the study

Exclusion criteria

* Any chronic condition requiring regular treatment or medical follow-up * Bleeding disorder or susceptible to prolonged or uncontrolled bleeding * Active infection * Current smoker * Subject has a BMI equal or greater than 30 * Use of oral contraceptives in the previous 3 months * Subject is pregnant or breast-feeding * Currently menstruating

Design outcomes

Primary

Measure	Time frame	Description
Change in whole blood viscosity from dehydrated state	120 min following rehydration	Blood viscosity measured using a scanning capillary viscometer

Secondary

Measure	Time frame	Description
Change in whole blood viscosity from dehydrated state	15, 30, 60, and 90 min following rehydration	Blood viscosity measured using scanning capillary viscometer
Change in plasma osmolality from dehydrated state	15, 30, 60, 90, and 120 min following rehydration	Plasma osmolality measured using freezing point osmometer
Change in bioelectrical impedance	45, 75, and 120 min following rehydration	Impedance is measured to provide an estimation of body composition using a bioelectrical impedance analyzer (RJL Quantum IV).
Body mass change	45, 75, and 120 min following rehydration	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026