Von Willebrand Factor to Predict Postoperative Outcome

Preoperative Von Willebrand Factor to Predict Postoperative Liver Dysfunction and Morbidity After Liver Resection

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02118545

Enrollment

133

Registered

2014-04-21

Start date

2014-04-30

Completion date

Unknown

Last updated

2016-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hospitalisation, Liver Dysfunction, Morbidity, Mortality

Keywords

vWF, Liver Resection, Liver Dysfunction, Liver Regeneration, Postoperative Outcome

Brief summary

vWF is stored in weibel-palade-bodies of endothelial cells as well as alpha-granula of platelets and is released upon their activation. Endothelial cell dysfunction as well as platelet activation often occur in liver disease and portal hypertension, which may lead to an increase in circulating vWF levels. Indeed, multiple studies have reported that liver disease is associated with increased circulating vWF- antigen (vWF-Ag). Furthermore, increased circulating vWF -Ag Levels have been shown to be associated with increased mortality rates in patients with chronic liver disease. Within a prospective evaluation cohort, the investigators were able to document that patients with increased vWF-Ag levels prior to liver resection suffered from an increased incidence of postoperative liver dysfunction and morbidity. Within this prospective multicenter validation study, the investigators now aim to prospectively validate that circulating vWF-Ag prior to liver resection is a valuable marker to predict postoperative clinical outcome.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* patients undergoing liver resection * only patients with either hepatocellular carcinoma, cholangiocellular carcinoma or colorectal cancer liver metastasis will be included

Exclusion criteria

* inherited coagulopathy * age \> 85

Design outcomes

Primary

Measure	Time frame	Description
Number of Participants with Postoperative Liver Dysfunction	90 postoperative days	Preoperative vWF-Ag Predicts Postoperative Liver Dysfunction after Liver Resection

Secondary

Measure	Time frame	Description
Number of Participants with Postoperative Morbidity	90 postoperative days	Preoperative vWF-Ag Predicts Postoperative Morbidity after Liver Resection
Number of Participants with Postoperative Mortality	90 postoperative days	Preoperative vWF-Ag Predicts Postoperative Mortality after Liver Resection
Days of Postoperative Hospitalisation	90 postoperative days	Preoperative vWF-Ag Predicts Postoperative Hospitalisation after Liver Resection

Countries

Austria, Switzerland

Outcome results