Obesity
Conditions
Keywords
obesity; fat distribution; inflammation
Brief summary
GLP-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state
Detailed description
As a treatment for type 2 diabetesGlucagon like peptide -1 (Glucan-like peptide-1, GLP-1) receptor agonists plays the role of promoting insulin secretion, inhibiting glucagon secretion，and also has the central and peripheral effects,it can inhibit appetite,reduce weight.GLP-1 receptor agonists promote fat redistribution in obese women with type 2 diabetes, reduce liver fat content, improve the inflammation state
Interventions
DRUGExenatide
5ug bid,Subcutaneous injection
Sponsors
Shanghai 10th People's Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of overweight and type 2 diabetes mellitus
Exclusion criteria
* Poor body condition (severe liver and kidney dysfunction) * Unknown causes of pancreatitis, chronic pancreatitis, pancreatic resection, stomach operation, malignant tumor, previous use of systemic corticosteroids (local or inhalation of exceptions) heart function or niacin, incomplete * serious endocrine disease * genetic disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dual energy X-ray absorptiometry | 3 month | fat distribution |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| lab testing | 3 month | inflammation |
Other
| Measure | Time frame | Description |
|---|---|---|
| lab testing | 3 months | liver function |
Countries
China
Contacts
Primary ContactYu Jie
Outcome results
None listed