Alcohol Intake, Sleep Deprivation
Conditions
Brief summary
Although the effects of acute alcohol intake and sleep deprivation on exercise performance lacks evidence in the literature, in many situations, they occur simultaneously. Once the alcohol affects physiological processes, the processes that occur during sleep can be impaired, such as: suppression of GH release, action of neurotransmitters and neuromodulators in the CNS, changes in the proportion of sleep stages and may lead to suppression of REM sleep. These changes promote a significant functional impairment such as a reduction in alertness and modification in reaction time, which affects the performance of any activity of daily and professional life. However, the combined effects on the physical performance variables, such as aerobic and neuromuscular performance lack of evidence in the literature.
Detailed description
Ten subjects were randomized in four situations after familiarization and control situation: (1) alcohol intake combined with sleep normal; (2) alcohol intake combined with sleep deprivation; (3) placebo intake combined with sleep normal and (4) placebo intake combined with sleep deprivation.
Interventions
OTHERAlcohol intake
The subjects will be drink beer (with or without alcohol) before sleep intervention (normal sleep and sleep deprivation).
OTHERSleep deprivation
One night of sleep deprivation or one night of normal sleep.
Sponsors
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Federal University of Rio Grande do Sul
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
\- Physical active men
Exclusion criteria
* AUDIT questionnaire above 15 points * Nocturnal Chronotype * Skeletal muscle injuries in upper and lower limb * Metabolic and cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aerobic Performance | After each sequence, up to 8 hours | Aerobic performance will be determined through the subject's heart rate |
| Neuromuscular Performance | After each sequence, up to 8 hours | knee extensor isometric torque |
| Biochemical Responses | After each sequence, up to 8 hours | Glucose after each situation in the morning |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hydration Status | After each sequence, up to 8 hours | Urine Specific Gravity |
| Profile of Mood States | 6 months | — |
| Breath Alcohol | 6 months | — |
Countries
Brazil
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| All Study Participants Received Alcohol intake + Normal Sleep Received Alcohol intake + Sleep Deprivation Received Placebo intake + Normal Sleep Received Placebo intake + Sleep Deprivation | 10 |
| Total | 10 |
Baseline characteristics
| Characteristic | All Study Participants |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 10 Participants |
| Age, Continuous | 23.5 years STANDARD_DEVIATION 3.3 |
| Gender Female | 0 Participants |
| Gender Male | 10 Participants |
| maximal oxygen uptake | 44.8 ml.kg-1.min-1 STANDARD_DEVIATION 2.4 |
| Region of Enrollment Brazil | 10 participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | — / — | — / — | — / — | — / — |
| other Total, other adverse events | 5 / 10 | 8 / 10 | 0 / 10 | 3 / 10 |
| serious Total, serious adverse events | 0 / 10 | 0 / 10 | 0 / 10 | 0 / 10 |
Outcome results
Primary
Aerobic Performance
Aerobic performance will be determined through the subject's heart rate
Time frame: After each sequence, up to 8 hours
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Sequence 1 | Aerobic Performance | 172 bpm | Standard Deviation 12.19 |
| Sequence 2 | Aerobic Performance | 173 bpm | Standard Deviation 9.2 |
| Sequence 3 | Aerobic Performance | 175 bpm | Standard Deviation 6.5 |
| Sequence 4 | Aerobic Performance | 176 bpm | Standard Deviation 11.4 |
Primary
Biochemical Responses
Glucose after each situation in the morning
Time frame: After each sequence, up to 8 hours
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Sequence 1 | Biochemical Responses | 89.82 mg/dl | Standard Deviation 6.6 |
| Sequence 2 | Biochemical Responses | 84.76 mg/dl | Standard Deviation 4.03 |
| Sequence 3 | Biochemical Responses | 92.77 mg/dl | Standard Deviation 5.13 |
| Sequence 4 | Biochemical Responses | 92.85 mg/dl | Standard Deviation 8.26 |
Primary
Neuromuscular Performance
knee extensor isometric torque
Time frame: After each sequence, up to 8 hours
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Sequence 1 | Neuromuscular Performance | 260.8 Nm | Standard Deviation 27.9 |
| Sequence 2 | Neuromuscular Performance | 242.3 Nm | Standard Deviation 34.3 |
| Sequence 3 | Neuromuscular Performance | 258.9 Nm | Standard Deviation 31.3 |
| Sequence 4 | Neuromuscular Performance | 249.5 Nm | Standard Deviation 33.9 |
Secondary
Breath Alcohol
Time frame: 6 months
Secondary
Hydration Status
Urine Specific Gravity
Time frame: After each sequence, up to 8 hours
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Sequence 1 | Hydration Status | 1.017 g/ml | Standard Deviation 0.006 |
| Sequence 2 | Hydration Status | 1.017 g/ml | Standard Deviation 0.005 |
| Sequence 3 | Hydration Status | 1.015 g/ml | Standard Deviation 0.003 |
| Sequence 4 | Hydration Status | 1.011 g/ml | Standard Deviation 0.006 |
Secondary
Profile of Mood States
Time frame: 6 months