Atherosclerosis
Conditions
Brief summary
The aim of this study is to examine the effects in humans of a moderate butter intake on risk markers of cardiovascular disease compared to a diet with the same amount of olive oil (refined and therefore without polyfenols). The primary parameters are total cholesterol, LDL- and HDL cholesterol and triglycerides. The secondary parameters are risk markers of diabetes type 2; plasma glucose and insuling as well as the inflammatory marker hs-CRP.
Interventions
OTHERDanish butter
The effect of butter intake versus olive oil (refined) intake on blood lipids (primarily)
OTHEROlive oil
Sponsors
The Danish Dairy Research Foundation, Denmark
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Sign written consent * Age: 20-70 y * BMI: 18.5 - 32 kg/m2 * Healthy men and women (with no known diseases)
Exclusion criteria
* Current or previously cardiovascular disease, high blood pressure * Diabetes Mellitus or other severe chronic disease, including severe allergies * Use of dietary supplements and blood donations prior to, and during the study * Known or suspected abuse of alcohol, drugs or medication * Pregnant or are planning pregnancy during the study period * Extreme physical activity level (more than 10 hours tough physical activity pr. week) * Participation in other research studies * Inability, physically or mentally, to comply with the procedures required by the study protocol, as evaluated by the study staff
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total cholesterol | 5 weeks |
| LDL cholesterol | 5 weeks |
| HDL cholesterol | 5 weeks |
| Triglycerides | 5 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Glucose | 5 weeks |
| hs-CRP | 5 weeks |
| Insulin | 5 weeks |
Countries
Denmark
Outcome results
None listed